Two Research Projects supported by
Birdshot Uveitis Society of North America
(June 2020 - June 2021)

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Dissecting Birdshot Chorioretinopathy with Visual Electrophysiology and Multimodal
Imaging: Detecting Disease Evolution and Drug Treatment Efficacy Through Sequential
ERG Monitoring and Retinotopic Mapping of Macular Function and Structure

Mélanie Hébert, MD

Anna Polosa, PhD

Marie-Josée Aubin, MD, MSc, MPH

There are now many new methods of imaging the eye which allow eye doctors to analyze
different structures and eye functions with greater details. These include electroretinography
(ERG), which can measure the reaction to light of the entire retina (full-field ERG) or multiple
small sections of the retina (multifocal ERG), and optical coherence tomography (OCT) which
can allow doctors to look at all the layers of the retina and the blood vessels of the retina with

Because Birdshot chorioretinopathy is a rare disease, not many studies have looked at
how these new technologies can be best used to monitor and manage this disease. We want to
study how ERG and OCT can be used to detect early signs of Birdshot chorioretinopathy. This
could allow doctors to initiate treatment earlier and better monitor treatment response to limit
damages. We want to compare these new technologies with existing tests that are already used
routinely, like visual field testing, fluorescein angiography, indocyanine green angiography, and
fundus autofluorescence. This could also help doctors understand whether and how these tests
are associated with vision and symptoms. We also want to study how the disease evolves using 

ERG and OCT. This may help to detect treatment efficacy more accurately and disease
progression before this has an impact on the vision or quality of life of patients.

We follow one of the largest groups of patients with Birdshot chorioretinopathy and
currently apply these new imaging technologies hoping to make faster diagnoses, better adjust
treatments, and improve the quality of life of Birdshot chorioretinopathy patients everywhere.